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Cyclodextrin reversing arterial plaque?

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  • Cyclodextrin reversing arterial plaque?

    This study found that cyclodextrin promoted the removal of cholesterol from arterial plaque in a mouse model and also in human atherosclerotic tissue in vivo:
    "Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming"

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878149/

    Treatment with CD caused a regression of 45% in arterial plaque - great news if you're a mouse!

    A Google search turned up this paper

    "Cyclodextrins as Emerging Therapeutic Tools in the Treatment of Cholesterol-Associated Vascular and Neurodegenerative Diseases"

    which is a literature survey of studies in the use of CD for CVD, Alzheimer's & Parkinson's among others. Apparently in addition to dissolving cholesterol CD also dissolves amyloid beta plaques, although given that Ab might be a protective feature maybe that's not such a good thing.

    Any thoughts on the use of CD for removing arterial plaque Dr Brewer?
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