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Rosuvastatin & Diabetes

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  • Rosuvastatin & Diabetes

    I am an age 53 male, 5" 10', 163 lbs. I exercise 5 days a week - both HIIT and resistance training . I have an LP (a) of 588 g/L and I'm taking 10 gr of rosuvastatin. My A1C is 5.6 and my fasting glucose is 100. I eat almost zero sugar and less than 100 carbs per day. Does any one have any suggestions on how to get my insulin blood sugar a little lower. I follow Dr. brewer's videos and the inflammation from the prediabetes has me quite concerned. Any suggestions? Thank you.

  • #2
    I have similar problem with FBG. It stays between 90-110 no matter what I eat or don't eat. It's called adaptive glucose sparing.
    I suppose you could take metformin, if you can find a doctor who will prescribe it. I can't.
    Also, 100 carbs/day is a lot. And your A1C is high, should be about 5.0.


    • #3
      We piloted our metformin service today. But it’s only if you’re in one of the 40 states where we’re licensed.


      • #4
        Usually a blood test report will have Lp(a) listed in mg/dL or nmol/L. Check and see because I can't quite tell if 588 really means mg/dL or if it is 58.8 mg/dL. There is a big difference between the two as far as risk goes. Same with the rosuvastatin dose as it is likely 10 mg/daily. It is important to get the units correct so that there is no misunderstanding.

        Take a look at your triglycerides and HDL-C levels to see what your triglyceride/HDL-C ratio is if you haven't had an advanced lipid panel. That ratio gives some indication of potential issues. Consuming 100 carbs/day isn't a lot for what many people take in, and I guess it depends upon whether you want to go into significant ketosis or not. There can be a lot of hidden carbs in processed foods in particular, and so your triglyceride levels will provide some insight in that potential. See this video on stealth carbs:

        As Dr. Brewer has said in more than one video I believe, a fasting blood glucose level could be high due to the dawn effect, or if you don't sleep well and your resulting cortisol levels are a bit high. You could try fasting for 24 hours to see how that goes with your fasting blood glucose level. Also vigorous exercise can temporarily increase your blood glucose value. If you don't have a blood glucometer, you should get one and check your response to the foods you typically eat. See the good video by John Lorscheider on this.

        Have you ever had a CAC score done or a CIMT test? You might want to do both to get a baseline of your cardiovascular health. If you are taking hypertension medication, consider using an ACE inhibitor over an ARB as there is a cardiovascular inflammation reduction advantage with an ACE inhibitor that doesn't happen with an ARB. Here is an older video on that. Also consider getting a MACR urine test (not blood test). MACR is micro-albumin/creatinine ratio.

        You would seem to be a good candidate for metformin. If you start taking metformin, see my post on metformin and exercise.
        Last edited by Tom; 06-28-2019, 01:04 AM.


        • #5
          Thank you everyone. I had a CT Cardiac done a year ago that showed 25-49% stenosis on my LAD. All others were less than 25%.

          I live in Vancouver, Canada and the number on my test report is for LP(a) is 588 in g/l. My triglycerides are 34, HDL is 72 and LDL 53. Tri/HDL is only .47.

          I seem to have bad genes but I have to keep working on this!


          • #6
            Your lipid values look excellent, and if your diet didn't change just before you had your lipid panel done I don't see any issues there. Lp(a) testing does have standardization issues, and if I try to fit the value you mention into what is typically seen in the US for mg/dL then it is too large to make sense. Could you provide the report's Lp(a) test reference range by chance and what the report said was a healthy level? Since you mentioned Lp(a), that likely is a concern to you. Some people use niacin to reduce their Lp(a) levels, but there hasn't been a randomized clinical trial on outcomes. I recently started a post on the forum about the development of some new drugs to reduce Lp(a).

            Back to your original point on blood glucose levels. As we age, insulin resistance becomes a more common issue that dieting and even fasting won't "cure". From what I can tell it is based upon how efficient our mitochondria are at converting glucose to ATP, and perhaps it is also influenced by epigenetic changes that occur for people at different rates as we age. I had thought a while back that quarterly five day water fasts over a two year period followed by healthy eating/exercise, etc. would help with my insulin resistance, but I always reset to the same insulin resistance point even though I lost weight and certainly ended up with less belly fat (overall less fat in my body). I have come to learn that I just have to live with that insulin resistance at age 64, and what counts is what I eat, when I eat, when I exercise and getting adequate sleep. I eat less carbs than I used to, and if I do eat a good amount of carbs I will go for a brisk walk to blunt the rise in blood glucose.


            • #7
              Thanks Tom, i just went online and checked, my LP(a) is 588 mg/l. 400 is 85 percentile, it's a world class number! Good news is my dad is age 87 though he did have bypass surgery at age 80 and doesn't take care of himself the way i do.. Main thing is he is above ground. I sure hope i can do that as well.


              • #8
                OK, I think that I understand now. Given what you have said, your greater risk going forward is likely your Lp(a) level. Dr. Brewer has mentioned that he has had some French Canadian patients with high Lp(a) levels such as yours, and I think that he told them to take niacin. The interesting thing is that the generic Lp(a) test actually measures the mass of all LDL family particles that have an Lp(a) attached, and that is a crude indication at best as the actual Lp(a) portion is relatively very small compared to the LDL particle overall mass.

                There is also a difference in Lp(a) risk depending upon how the Lp(a) particle has the kringle IV area made. If you don't know about the details but would like to learn, I can recommend some info. Peter Attia has a couple of good podcasts on Lp(a). The first podcast listed below is a generic Lp(a) podcast by Peter Attia himself, and the second podcast is Peter Attia talking with Tom Dayspring (listen to the minutes 2:30-17:00 portion in particular). The show notes are exceptional, but you have to pay a subscription fee to see those. You could probably find enough equivalent Lp(a) structures showing the kringle IV differences out on the Internet.

                Dr. Brewer also has several Lp(a) videos which you should watch. Here are a couple of examples.

                Last edited by Tom; 06-28-2019, 11:34 PM.