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Listen and learn about CVD and Lipids from Ken Sikiris

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  • Listen and learn about CVD and Lipids from Ken Sikiris

    https://www.youtube.com/watch?v=2p-mkbNutvQ&t=11s

    https://www.youtube.com/watch?v=o9PHHMvTe1Q

  • #2
    I thought that both videos provided good info for a general audience. I think that there are some nuances. The focus on triglycerides as part of the metabolic syndrome was important, and this sadly hasn't been given enough attention in general. Ken Sikaris didn't seem to know why VLDL particles collapse down to sdLDL particles, and that is because of the presence or absence of a few key proteins (APOE and APOCIII). Here is a study which explains those. https://www.ncbi.nlm.nih.gov/pubmed/11034934

    When a person has high levels of triglycerides (>130 md/dL and maybe lower for some people), their liver makes more VLDL particles as otherwise the liver will make more IDL and LDL particles directly. This is how niacin works to specifically lower sdLDL particle levels. Niacin lowers triglyceride generation, which in turn lowers the requirement for VLDL particle generation. Fewer VLDL particles means fewer sdLDL. The inability of the liver to clear the VLDL generated LDL particles results in those having a long transient time in the blood, which makes sdLDL so atherogenic.

    The second video is good but the material is dated. While an A1C test is better than FBG, it misses a substantial portion of the people in the early stages of diabetes. The recent update of the standards for detecting diabetes is for an OGTT. https://www.endocrinologyadvisor.com...form=hootsuite

    Comment


    • fatmax
      fatmax commented
      Editing a comment
      Somehow, I doubt there is anything about VLDL that Sikaris doesn't know.
      The Kraft survey has been long recognized as the best method of early diagnosis of prediabetes.

    • Tom
      Tom commented
      Editing a comment
      Fatmax, That is a Dec 2018 video you posted with Ken Sikaris talking about how adequate A1C is for diagnosing diabetes. He probably knows enough I would guess given that most people still only get a FBG done yearly until they suddenly become diabetic. If he would have focused on the Kraft Insulin survey that would have been a much more relevant video. Did you ever wonder why he is an A/Prof at his age (yes, I read his bio)?
      Last edited by Tom; 06-11-2019, 12:03 AM.

  • #3
    Yes, I've been wondering so much that it's keeping me up at night.

    It's probably because he's full time running a major lab doing useful work rather than playing status games in academia.
    Remember this quote from H.K.: "Academic politics are so vicious precisely because the stakes are so small."

    Here's an informative interview with him:
    http://2ketodudes.com/show.aspx?episode=117
    Last edited by fatmax; 06-11-2019, 05:44 AM.

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    • #4
      Ah yes, academia. Well just over 40 years ago a wise full Professor of the Electrical Engineering Dept where I was studying explained to me the difference between A/Profs and Profs because I thought that A/Profs were getting the short end of the stick so to speak. He basically said that A/Profs are competent, and help with teaching undergrads (especially in the lower level courses), running labs, and those sorts of things. A/Profs are very valuable people to have in the department, but they are not the jewels of the department and are replaceable when necessary. The Profs are there to do research as their main focus. They don't run a lab, they direct the research in THEIR lab. Sometimes in their lab they direct a mixture of A/Profs, graduate students and maybe the occasional undergrad senior. If you look around at who is making a lot of the discoveries in medicine and science in general, it is the Profs with their labs. Perhaps the quote that you listed is applicable for something like humanities, but research in hard sciences is an altogether different matter. It helps to understand the difference in order to separate trivia from reality.

      Comment


      • fatmax
        fatmax commented
        Editing a comment
        Gosh, thanks for your insight in separating trivia from reality. Now I understand that when I was studying physics 45-50 years ago, there was no inter/intradepartmental politics between the science faculty.

        Here's another interview with A/Prof Ken Sikiris:
        https://www.lowcarbconversations.com/?p=4228

      • Tom
        Tom commented
        Editing a comment
        I never said that there isn't inter/intradepartmental politics between the science faculty at a university, and why do you keep misspelling his name?

    • #5
      Here's Sikaris talking about himself and his career:
      https://knowpathology.com.au/?s=sikaris&post_type=post

      Comment


      • #6
        Please be polite.

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