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Niacin - Release formula (Immediate, Extended, Sustained, Controlled?, Prolonged?)

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  • Niacin - Release formula (Immediate, Extended, Sustained, Controlled?, Prolonged?)

    I have searched the forums and read the wonderful summary by John Lorscheider here and can't find this answer.

    According to this article there are three (3) standard release formulations of niacin (nicotinic acid):

    Release Flush Potential Liver impact
    Immediate Most Least
    Extended Medium Medium
    Sustained Least Most

    Some manufacturers follow this naming convention. Unfortunately, some use a different convention. How can we determine exactly what category they are?

    In particular:

    Slo-Niacin is listed as Controlled-Release
    21st Century is listed as Prolonged Release

    John lists Endur-Acin, Rugby and Slo-Niacin in the same category which suggests that Slo-Niacin is Extended release.

    How can we be sure it isn't sustained release? Same for 21st Century.

  • #2
    I take Slo-Niacin, and I can't speak to 21st Century product other than to say that the one product I noted on Amazon contained inositol hexanicotinate which isn't going to do much for lipids (maybe 21st Century has other niacin products). I suspect that the company making Slo-Niacin wants to emphasize their polygel release method which may be different from the packaging technology used by other companies. As Slo-Niacin has been on the market for so long, I don't believe that it is a sustained release product in the sense of other sustained release products that were associated with higher instances of liver problems. However, there is still risk especially at higher doses. If you follow Chris Masterjohn, he believes that at least some of the toxicity issues with niacin supplementation is due to depletion of methyl groups, and he recommends taking a TMG supplement to offset that methyl group loss.