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  • Nad

    What do you think about this?

  • #2
    Yes, that is an intriguing article. Unfortunately, Sinclair himself says he hasn't proven that NAD+ (nicotinamide adenine dinucleotide) works. The only thing for sure is that the one randomized controlled trial so far showed that taking NAD+ increased their NAD+ blood levels but it didn't show any benefit. He seems to have a streak in him to be the first once on the market with a new product. I remain skeptical. The good news though is that it seems there are no adverse effects reported yet from taking NAD+.


    • #3

      I share some of that skepticism.


      • #4
        I had been hopeful that some hard science would eventually be published to validate the NR claims, but some of the latest news isn't what I expected. From what I can tell, NR given orally gets taken up by the liver and converted to nicotinamide which is then provided to other tissues as noted in the referenced Cell article.

        NR consumption does increase NAD+ levels in the blood, but it is not clear as to whether that NAD+ can enter any other cells directly and add to their overall NAD+ pool. So, perhaps NR does something good for the liver NAD+ pool in converting NR to NAD+ directly using an NR kinase, but beyond that the benefits aren't obvious to me. If I understand correctly oral niacin also gets converted to nicotinamide in the liver, and it costs a lot less.


        • #5
          Yes, you understand correctly that niacin is a precursor for, and will convert to, NAD+. Here’s an study that explains that synthesis in detail.

          I take 2,000 MG per day of niacin in the nicotinic acid form so taking NAD+ supplements will unlikely offer additional benefit.


          • #6

            I just heard a podcast with David Sinclair, and it reminded me of something that I had noted in passing in the past. David Sinclair basically said that the reason that NR and now his preferred NMN molecule gained initial favor was that nicotinamide early on was known to suppress sirtuin2 activity (see attached study showing that from quite a while ago). Interesting given that the recent Cell article indicated that NR at least is converted to nicotinamide in the liver (as is niacin) which then goes throughout the body. Perhaps over time we will get some clarification that indicates this particular aspect is something other than bad overall. Yes, NAD+ goes up as a positive aspect, but it also ramps down sir2 activity. There are seven sirtuins, so NAD+ going up might increase activation of one or more of the other sirtuiins for an overall positive balance. Well, like everything we learn about metabolic pathways that initially seems so straightforward, there is always something (as Dr. Brewer says).